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KMID : 0363320050260020420
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Journal of Korean Oriental Internal Medicine
2005 Volume.26 No. 2 p.420 ~ p.430
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Protective Effects of Omijatang on Oxidative Stress-Induced Apoptosis of H9c2 Cardiomyoblast Cells
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Choi Jin-Young
Lee Yun-Jae
Shin Sun-Ho
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Abstract
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The water extract of Omijatang(OMJT) has been traditionally used for treatment of abscess and heart palpitation in oriental medicine, However, little is known about the mechanism by which the water extract of OMJT rescues cells from these damages. This study was designed to investigate the protective mechanisms of OMJT in H9c2 cardiomyoblasts on oxidative stress-induced cytotoxicity including H_2O_2,;ZnCl_2, hypoxia, and reoxygenation. Oxidative stress markedly decreased the viability of H9c2 cells. This was characterized with apparent apoptotic features such as chromatin condensation as well as fragmentation of genomic DNA and nuclei. However, OMJT significantly reduced H_2O_2-induced cell death and apoptotic characteristics as well as ZnCl_2, hypoxialreoxygenation. Taken together, this study suggests that the water extract of OMJT has the protective effects against oxidative injuries.
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KEYWORD
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Omijatang, cardiomyoblast, oxidative stress, cytotoxicity, H_2O_2, ZnCl_2
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